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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) greater than 27, given that they also suffer from weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder in addition to being an aid to quitting smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that includes a reduced-calorie dieting and exercise, Contrave provides another treatment option for chronic weight-loss for people who are obese or are overweight and possess at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of four years old.1% rather than participants who were given placebos) throughout a 12- month period, while a different study involving patients with type 2 diabetes had an average weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to shed pounds can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with fat loss and the individuals who go through it one should err assisting caution and permit the FDA do its job and demand some investigation be done so that the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies will be in business to generate income and that they would say almost anything to keep people on the medications.

Researchers discovered that participants investing in this drug for a year, lost weight within four weeks and have kept the extra weight off during the entire 56 weeks of the study. Contrave is really a combination from the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs that are made up of many active ingredient, which might make them far better and safer.

Combo-pilling could be the newest fad or also the newest ahead under scrutiny and thus it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is becoming popular could be the fact that since right now there are no long term prescription slimming capsules that have been authorized by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be licensed by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug also can raise blood pressure levels and heart rate, and shouldn't be used in people who have a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure level and heart rate and must not be used in patients with uncontrolled high blood pressure levels, as well as by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients on the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.


New UCLA study on smokers with mental, drug, and alcohol problems